Hyderabad-based Organic E tied up with Calgary-based Providence Therapeutics to fabricate its mRNA technology-based Covid-19 vaccine and do clinical trials in India. The deal assumes significance as this gives India access to the mRNA technology.
The vaccine, named PTX-COVID19-B, is under development in Canada this present day. Providence announced data from the phase 1 trials in May and will begin the phase 2 trials soon.
“The mRNA platform has emerged as the front runner in delivering the first vaccines for emergency use to combat the COVID-19 pandemic. Organic E. is very pleased so as to work with Providence on its promising mRNA vaccine candidate. We are hoping to supply India and other countries yet an alternative choice to ramp up their efforts towards achieving herd immunity against COVID-19,” said Mahima Datla, Managing Director of Organic E Limited.
While the financial terms of the deal were not disclosed, Providence will sell up to 30 mn doses of its mRNA vaccine to Organic E. It would also give you the essential technology transfer to make the vaccine in India, with a minimum production capacity of 600 mn doses in 2022 and targets capacity of 1 bn doses.
“Organic E will be responsible for all clinical development and regulatory activities for the mRNA vaccine in India and other jurisdictions licensed by Organic E,” the company said.
“This initiative is the most important commitment by a Canada-based company to help India and other nations vaccinate their citizens against COVID19. Providence used to be founded to serve patients, and this commitment by Organic E allows us to succeed in that fundamental goal,” indicated Brad Sorenson, CEO of Providence.
Organic E already has a deal in place to make over 500 mn doses of the unmarried dose Johnson and Johnson (J&J) vaccine. J&J’s is a viral vector based vaccine which uses human adenovirus Ad26.
India already has one mRNA vaccine in development by Pune-based Gennova Biopharmaceuticals which is in phase 1 clinical trials.
In a May 12 press commentary, Providence has said that its phase 1 studies on 60 subjects have shown PTX-COVID19-B to be in most cases secure and polite tolerated. It exhibited “strong virus neutralisation”. It already has an agreement in place to provide 2 mn doses of PTX-COVID19-B to the government of Manitoba in Canada.
According to media reports, Providence used to be planning to move the clinical trials out of Canada.
Aside from the J&J and Providence Covid-19 vaccine deals, Organic E also has under development a third candidate with Baylor College of Medicine. The Baylor College of Medicine – Organic E vaccine is set to start phase 3 clinical trials in June. It is a protein sub-unit technology based vaccine, a technology that Organic E already had. This technology is used to make Hepatitis B vaccines.
The Indian government has indicated that in the second one half of the year, it expects to get 300 mn doses of the Organic E vaccine.
India is already in talks with US players Pfizer and Moderna for bringing their USFDA-approved mRNA Covid-19 vaccines to India. Canada is the usage of both Pfizer and Moderna vaccines to inoculate its citizens.
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