E-cigarette users may have increased susceptibility to Covid-19 – health

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In a controlled study of smokers, nonsmokers, and e-cigarette users, University of North Carolina School of Medicine researchers found that e-cigarette users exhibited significantly altered immune responses to a mannequin of influenza virus infection, suggesting increased susceptibility to disease.

The findings, published in the American Publication of Respiratory Cell and Molecular Biology, show that vaping changes the expression of genes and production of proteins in respiratory cells, in addition to altering virus-specific antibody production.

“In lots of the study participants, we observed more changes to the immune response in e-cigarette users than we did in smokers,” said first creator Meghan Rebuli, PhD, assistant professor in the UNC Branch of Pediatrics and member of the UNC Center for Environmental Medicine, Asthma, and Lung Biology.

“All of these factors have the potential to adversely impact response to a virus and immunity post-infection. While we used influenza as a mannequin, this suggests that e-cigarette users are likely more susceptible to respiratory viruses than are non-smokers, and this likely includes SARS-CoV-2, the virus that causes coronavirus disease 2019 (Covid-19),” added Rebuli.

The main reason to keep away from smoking is the risk of cancer, heart disease, emphysema, stroke, diabetes, chronic obstructive pulmonary disorder, and other lung diseases. For these reasons, researchers also have been studying the potential effects of electronic cigarettes, which are composed of thousands of chemicals many of which are FDA-approved for ingestion, but not inhalation.

But for a few years, inhalation of tobacco smoke has also been linked to increased risk of viral infection, such as influenza. Inhalation of e-cigarette aerosols has also been linked to immune suppression inside the respiratory tract, specifically the protective mucosal layer lining the within the nasal cavity.

Rebuli, senior creator Ilona Jaspers, PhD, and colleagues, thought that changes in the nasal mucosal immune response could modify antiviral host defence responses in e-cigarette users.

This is important because viruses, including the flu and SARS-CoV-2, have been shown to contaminate nasal cavities where they may be able to replicate in cells, spread all through the respiratory system, and be transmitted to other people.

Jaspers, the director of the UNC Center for Environmental Medicine, Asthma, and Lung Biology, has led preceding experiments showing that vaping altered hundreds of genes in epithelial cells involved in the body’s natural immune defence. For the current study, the researchers wanted to study what happens when e-cigarette users are exposed to a respiratory virus.

For the study, non-smokers, cigarette smokers, and e-cigarette users, age 18-40, were inoculated with live attenuated influenza virus (LAIV) vaccine – a well-established mannequin of influenza infection in the Jaspers lab- to safely inspect innate immune response.

Pre- and post-inoculation, the researchers collected nasal epithelial lining fluid, nasal lavage fluid, nasal scrape biopsies, urine, and blood. The scientists examined cytokines and chemokines, influenza-specific Immunoglobulin A (IgA), immune gene expression, and markers of viral load.

The researchers found that though the amount of markers of viral load did not vary some of the three groups, expected increases in nasal epithelial lining fluid anti-LAIV IgA – which is a potential indicator of developed immunity post-infection – did not arise in e-cigarette users and cigarette smokers.

Further, LAIV-induced gene expression changes in nasal biopsies differed in cigarette smokers and e-cigarette users as in comparison to non-smokers, with a greater number of genes changed in e-cigarette users, mostly resulting in decreased expression of immune genes critical for defence against viruses and generation of immune reminiscence.

“This isn’t good. We need to see IgA levels increase right through infection. It’s the body’s natural way to defend against an invader. Here we saw that both smoking and e-cigarette use hampers IgA levels,” Jaspers said.

“The suppressed expression of important immune genes may be concerning and in line with an overall suppression of appropriate immune responses,” added Jaspers.

In addition, altered immune response in e-cigarette users and cigarette smokers could make vaccines less effective in these groups.

“We don’t realize for certain whether people who vape are more susceptible to Covid-19, or whether vaccines would be less effective for them. But we realize we never need to see suppression of genes, proteins, and antibodies involved in our immune response. And this is what we see in our data related to smoking and e-cigarette use,” Rebuli said.

(This story has been published from a wire agency feed without modifications to the text.)

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