Here’s why knee osteoarthritis ends up in functional limitations and even disability in patients – fitness


To better understand why the change in the Osteoarthritis pain experience occurs, researchers from the Boston University Schools of Medicine (BUSM) and Public Health reviewed data from the Multicenter Osteoarthritis Study approximately the pain experience of 2,794 older adults with or at risk of knee osteoarthritis.

The study was once published in the publication Arthritis Care & Research.

Osteoarthritis is the most typical form of arthritis worldwide, affecting more than 300 million people. It causes substantial pain, functional limitations, and disability in patients.

The pain experienced in patients with knee osteoarthritis changes through the years. People first of all experience primarily weight-bearing related pain, such as with jogging and stair-climbing. Through the years, the pain becomes more persistent and can flare unpredictably.

They found that people with more pain sensitisation were much more likely to be afflicted by fixed and unpredictable pain, somewhat than just intermittent pain. This study has identified for the first time a potential underlying mechanism in the nervous system responsible for why people experience varying pain patterns with knee osteoarthritis.

“Our findings make stronger the clinical relevance of neurobiological mechanisms that impact the pain experience in knee osteoarthritis, including not only the severity of pain, but if the pain is intermittent or fixed, and if the pain is unpredictable,” said senior creator Tuhina Neogi, MD, PhD, professor of medicine and epidemiology at Boston University School of Medicine.

By understanding the different mechanisms that contribute to the pain experience of knee osteoarthritis, healthcare providers can begin to personalise pain management to each and every patient. For instance, whether a patient has pain sensitisation, therapies that can alter those nervous system signalling pathways could also be helpful. This would toughen the current ‘one-size-fits-all’ approach, in which each and every patient is started with the same remedy and then moved on to something else whether the first approach did not work.

“By understanding these mechanisms, determining ways to identify those mechanisms in the clinic, and developing treatments to target those mechanisms, we will be able to supply better management options to the millions of people worldwide with osteoarthritis,” said Dr Neogi.

(This story has been published from a wire agency feed without modifications to the text. Only the headline has been changed.)

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