Losing weight could prevent or even reverse diabetes, according to late-breaking research.
The research used to be presented on Monday at ESC Congress 2020.
In 2019, about 463 million people worldwide had diabetes, of which the huge majority (around 90 per cent) kind 2 diabetes. Diabetes doubles the risk of coronary heart disease, stroke, and death from cardiovascular disease. Obesity is the main modifiable cause of kind 2 diabetes, while genetic make-up may additionally identify individuals with a greater likelihood of developing the condition.
“Because we are born with our genes, it might be conceivable to pinpoint early in life who has a high chance of developing diabetes all the way through their lifetime,” said principal investigator Professor Brian Ference of the University of Cambridge, UK, and the University of Milan, Italy. “We conducted this study to find out whether combining inherited risk with current body mass index (BMI) could identify people at the highest risk of developing diabetes. Prevention efforts could then be aware of these individuals.”
The study included 445,765 participants of the United Kingdom Biobank. The average age used to be 57.2 years and 54 per cent were women. Inherited risk of diabetes used to be assessed the use of 6.9 million genes. Height and weight were measured at enrolment to calculate BMI in kg/m2. Participants were divided into five groups according to the gc of diabetes. They were also divided into five groups according to BMI.
Participants were followed-up until an average age of 65.2 years. All through that period, 31,298 developed kind 2 diabetes.
Those in the highest BMI group (average 34.5 kg/m2) had an 11-fold increased risk of diabetes in comparison to participants in the lowest BMI group (average 21.7 kg/m2). The highest BMI group had a greater likelihood of developing diabetes than all other BMI groups, without reference to genetic risk.
“The findings indicate that BMI is a a lot more powerful risk factor for diabetes that genetic predisposition,” said Professor Ference.
The investigators then used statistical methods to estimate if the likelihood of diabetes in people with a high BMI would be even greater whether they were overweight for a long time frame. They found that the duration of elevated BMI did not have an have an effect on on the risk of diabetes.
Professor Ference said: “This suggests that when people cross a sure BMI threshold, their chances of diabetes go up and stay at that same high-risk level without reference to how long they’re overweight.”
He famous that the threshold is likely different for each and every person and will be the BMI at which they start to develop peculiar blood sugar levels. Professor Ference said: “The findings indicate that most cases of diabetes could be have shyed away from by keeping BMI below the cut-off which triggers peculiar blood sugar. Which means to prevent diabetes, both BMI and blood sugar must be assessed often. Efforts to lose weight are critical when a person starts to develop blood sugar problems.”
“It will also be conceivable to reverse diabetes by losing weight in the early stages before permanent damage occurs,” said Professor Ference.
(This story has been published from a wire agency feed without modifications to the text. Only the headline has been changed.)
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